An effective immunotherapy approach for ovarian cancer

Year 2024
Project team Paula Hammond & Darrell Irvine with Ivan Pires

250K women in US affected by ovarian cancer
Fifth leading cause of cancer-related deaths among women worldwide
~70% of patients have a recurrence that is non-responsive to standard chemotherapies

Ovarian cancer affects over a quarter million women in the U.S., with most diagnoses at late stages, limiting effective treatment options. This team employs electrostatically assembled layer-by-layer nanoparticles that target disseminated tumors to safely deliver an immunostimulatory treatment to the surface of cancer cells. This mounts a strong immune defense against tumors. Deployment of this therapy could enhance therapeutic efficacy, introduce a memory response that addresses recurrence, and minimize treatment toxicity.