Novel approaches to antibody-drug conjugates
Year
2015
Project team
Stephen Buchwald & Bradley Pentelute with Timothy Senter, Chi Zhang & Kashif Khan
New chemical linkers in cancer therapy
Antibody-Drug Conjugates (ADCs) for cancer therapy are synthesized by attaching cytotoxic small molecule drugs to monoclonal antibodies, using chemical linkers. The team is developing novel linkers to attach drugs to antibodies. These linkers should allow for a much more effective cancer therapy.